Journal: Frontiers in Pharmacology
Article Title: Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses
doi: 10.3389/fphar.2022.1042189
Figure Lengend Snippet: Animal and clinical studies of different Lactobacillus strains in alleviating inflammatory diseases pertaining to different organs.
Article Snippet: The proposed mechanism of action includes: 1) Bile salts degradation through the action of microbial bile salt hydrolase (BSH), making them relatively less soluble and thus reducing their reabsorption by the intestinal epithelial layer and increasing their excretion in feces as observed in L. gasseri LBM220 ( ) and L. mucosae SRV5 and SRV10 ( ) 2) Microbial conversion of cholesterol to relatively soluble form coprostanol which can readily assimilate and excreted out via feces 3) Incorporation of cholesterol by the microbial membrane as observed in strain L. acidophilus ATCC 43121 4) production of short chain fatty acids (SCFA).
Techniques: Expressing, Blocking Assay